Syracuse Police say two Hispanic men, ages 34 and 33, were shot multiple times in the 100 block of Holden Street at about 6:15 p.m.
Both victims were taken to Upstate University Hospital.
The 34-year-old victim was pronounced dead in the emergency room.
The 33-year-old victim is in critical condition and undergoing emergency surgery.
Police say they have no suspect information at this time and call the investigation very active and ongoing.
It is believed that the victims along with the other shooting victims from this weekend's violence have all been targeted, according to police.
But, it is unknown at this time if the shootings are related.
Anyone with information about the shooting or any of the other shootings that took place in the past 48 hours is asked to contact the Syracuse Police at (315) 442-5222.
All calls will be kept strictly confidential.
Copyright 2015 Nexstar Broadcasting, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.