The No. 5 seed Orange (22-9) now await the NCAA Division I Women's Basketball Selection Show on Monday, March 17 at 7 p.m. on ESPN.
Brittney Sykes led Syracuse with 14 points to go with 8 rebounds and 2 blocks. Brianna Butler, Rachel Coffey and La'Shay Taft each added 9 points for the Orange, which shot 34.3 percent, including 9-of-32 from 3-point range.
Markeisha Gatling led the Wolfpack with 28 points and Kody Burke had 21 points and 16 rebounds in addition to 5 assists.
NC State shot 44.4 percent overall and 6-of-16 from behind the arc.
After a Butler 3-pointer gave the Orange a 9-point lead with 15:35 remaining, NC State went on a 25-1 run with all but the final 3 points coming from Burke and Gatling to take control, 64-49, with 8:08 to go.
The Orange missed 16-straight field goal attempts before a Briana Day put-back with 7:44 left ended the almost eight-minute drought.
Within the run, there were three extended stoppages due to power issues at the Greensboro Coliseum related to an ice storm.
Sykes converted a 3-point play with 1:24 on the clock to make it a 9-point game again, 72-63, but NC State went 7-of-8 from the free throw line over the duration to ice the victory.
Sykes' 14 points gives her a season total of 519, the fifth-most in program history.
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