BUFFALO, N.Y. (WIVB) — The Bills will be without All-Pro linebacker Matt Milano and starting defensive tackle DaQuan Jones for a significant amount of time. Both will require surgery for injuries sustained Sunday during a 25-20 loss to the Jaguars in London.

Milano was carted off the field with a right leg injury in the first quarter, shortly after Jones hurt his pectoral muscle. McDermott did not state whether either player is out for the season, but indicated both will be out of the lineup for a long duration.

On the offensive side of the ball, tight ends Dawson Knox (wrist) and rookie Dalton Kincaid (concussion) came back from London with injuries.

According to an NFL Network report, Milano fractured his right leg and sustained further damage to his knee.

The injuries left the Bills down five defensive starters in the fifth game of the season, even after star pass rusher Von Miller and safety Jordan Poyer returned from injury Sunday.

Top cornerback Tre’Davious White is out for the season after rupturing his Achilles tendon in last week’s win against the Dolphins, while another starting cornerback Christian Benford (shoulder) did not play against the Jaguars. Starting defensive end Greg Rousseau (foot) and reserve Shaq Lawson (toe) also were inactive for the Bills.

Rookie linebacker Dorian Williams initially replaced Milano in the Bills’ base defense alignment next to Terrel Bernard, and veteran Tyrel Dodson took over later on, while Jordan Phillips and Tim Settle rotated in at Jones’ spot on the line.

Miller made his season debut in London, returning 10 months after tearing ligaments and cartilage in his knee. Miller played limited snaps against the Jaguars, mostly on passing downs. Poyer started after missing one game with a knee injury.

Milano was injured while pressuring Jaguars quarterback Trevor Lawrence on a third down play in the red zone. He made three tackles before exiting, brining his season total to 30. He is tied with Bernard and safety Micah Hyde for the team lead with two interceptions.

A fifth-round draft pick by the Bills in 2017, Milano was selected first team All-Pro by the Associated Press last season.

The Associated Press contributed reporting.